Xuewei Wang , Ph.D.
B.S., Shanxi University, China
Ph.D., University of Chinese Academy of Sciences, China
JDRF Advanced Postdoctoral Fellow, University of Michigan Ann-Arbor
Honors and Awards
Hypoparathyroidism Grant Program Award from the Orphan Disease Center, 2020
JDRF New Faculty Transition Award, 2019
Exercise and Sport Science Initiative Award at the University of Michigan, 2018
JDRF Advanced Postdoctoral Fellowship, 2017
Presidential Award of Chinese Academy of Sciences, 2013
Chemical Sensors and Microfluidics for Medical Diagnostics
We have been interested in developing portable, wearable, implantable, and microfluidic chemical sensors for health monitoring and disease diagnosis outside of hospital settings. Current efforts include the design of ionophore-based ion-selective electrodes/nano-optodes, molecular probe-based colorimetric bacteria sensors, enzyme-based continuous glucose monitors, and fluorescent chemical sensing platforms in droplet microfluidics.
Biocompatible Medical Implants Based on the Release of Nitric Oxide
Nitric Oxide is a natural molecule with potent anti-thrombotic, bactericidal, anti-inflammatory, and pro-angiogenic properties. We are developing various nitric oxide release/generation strategies to reduce foreign body reactions to biomedical implants like sensors, catheters, and cannulas. Of particular interest are nitric-oxide releasing insulin infusion cannulas used for prolonged subcutaneous insulin delivery and nitric oxide-releasing catheters used to prevent urinary tract infections.
R. Wang, Y. Zhou, N. Ghanbari Ghalehjoughi, Y. Mawaldi, X. Wang. Ion-Induced Phase Transfer of Cationic Dyes for Fluorescence-Based Electrolyte Sensing in Droplet Microfluidics. Analytical Chemistry, 2021, https://doi.org/10.1021/acs.analchem.1c03394
W. Li, Y. Yang, C. J. Ehrhardt, N. Lewinski, D. Gascoyne, G. Lucas, H. Zhao, Xuewei Wang. 3D Printing of Antibacterial Polymer Devices Based on Nitric Oxide Release from Embedded S-nitrosothiol Crystals. ACS Applied Bio Materials, 2021, https://doi.org/10.1021/acsabm.1c00887
B. Brady, R. Wang, R. Cheong, X. Wang. Digital Printing of Selective and Reversible Ion Optodes on Fabrics: Toward Smart Clothes for Epidermal Chemical Sensing. Analyst, 2021, https://doi.org/10.1039/D1AN01349A
R. Wang, X. Wang. Sensing of Inorganic Ions in Microfluidic Devices. Sensors and Actuators B: Chemical, 2021, 329, 129171
Q. Zhang, X. Wang, V. Decker, M. E. Meyerhoff. Plasticizer-Free Thin-Film Sodium-Selective Optodes Inkjet-Printed on Transparent Plastic for Sweat Analysis. ACS Applied Materials & Interfaces, 2020, 12, 25616–25624
X. Wang, Y. Zhou, V. Decker, M. E. Meyerhoff, M. Sun, Y. Cui. Plasticizer-Free and pH-Independent Ion-Selective Optode Films Based on a Solvatochromic Dye. Analytical Methods, 2020, 12, 2547-2550
Prior to VCU
X. Wang, M. Sun, S. A. Ferguson, J. D. Hoff, Y. Qin, R. Bailey, M. Meyerhoff, Ionophore‐Based Biphasic Chemical Sensing in Droplet Microfluidics. Angewandte Chemie International Edition, 2019, DOI: 10.1002/anie.201902960.
Y. Cui, X. Wang, H. Zhang, H. Li. M. Meyerhoff, Colorimetric Copper Ion Sensing in Solution Phase and on Paper Substrate Based on Catalytic Decomposition of S-Nitrosothiol. Analytica Chimica Acta, 2019, 1053, 155-161.
X. Wang, A. Jolliffe, B. Carr, Q. Zhang, M. Bilger, Y. Cui, J. Wu, X. Wang, M. Mahoney, A. Rojas Pena, M. J. Hoenerhoff, J. Douglas, R. H. Bartlett, C. Xi, J. L. Bull, M. E. Meyerhoff, Nitric Oxide-Releasing Semi-Crystalline Thermoplastic Polymers: Preparation, Characterization and Application to Devise Anti-Inflammatory and Bactericidal Implants. Biomaterials Science, 2018, 6, 3189-3201.
X. Wang, M. Mahoney, M. E. Meyerhoff, Inkjet-Printed Paper-Based Colorimetric Polyion Sensor Using Smartphone as a Detector. Analytical Chemistry, 2017, 89, 12334–12341
X. Wang, Q. Zhang, C. Nam, M. Hickner, M. Mahoney, M. E. Meyerhoff, An Ionophore‐Based Anion‐Selective Optode Printed on Cellulose Paper. Angewandte Chemie International Edition, 2017, 56, 11826-11830
X. Wang, Y. Qin, M. E. Meyerhoff, Paper-Based Plasticizer-Free Sodium Ion-Selective Sensor with Camera Phone as a Detector. Chemical Communications, 2015, 51, 15176-15179.
X. Wang, A. S. Balijepalli, M. E. Meyerhoff, Polyion-Sensitive Polymeric Membrane-Based Pulstrode as a Potentiometric Detector in Liquid Chromatography. Electroanalysis, 2015, 27, 1823–1828.
X. Wang, Y. Yang, L. Li, M. Sun, H. Yin, W. Qin, A Polymeric Liquid Membrane Electrode Responsive to 3,3′,5,5′-Tetramethylbenzidine Oxidation for Sensitive Peroxidase/Peroxidase Mimetic-Based Potentiometric Biosensing. Analytical Chemistry, 2014, 86, 4416–4422.
X. Wang, D. Yue, E. Lv, L. Wu, W. Qin, Reporter-Free Potentiometric Sensing of Boronic Acids and Their Reactions by Using Quaternary Ammonium Salt-Functionalized Polymeric Liquid Membranes. Analytical Chemistry, 2014, 86, 1927–1931.
X. Wang, Z. Ding, Q. Ren, W. Qin, Polymeric Membrane Neutral Phenol-Sensitive Electrodes for Potentiometric G-quadruplex/Hemin DNAzyme-Based Biosensing. Analytical Chemistry, 2013, 85, 1945–1950.
X. Wang, W. Qin, Tetra(p-tolyl)borate-Functionalized Solvent Polymeric Membrane: a Facile and Sensitive Sensing Platform for Peroxidase and Peroxidase Mimetics. Chemistry-A European Journal, 2013, 19, 9979-9986.
X. Wang, W. Qin, Reactive Tntermediates-Induced Potential Responses of a Polymeric Membrane Electrode for Ultrasensitive Potentiometric Biosensing. Chemical Communications, 2012, 48: 4073-4075.
X. Wang, Q. Wang, W. Qin, A Moving-Part-Free Protamine-Sensitive Polymeric Membrane Electrode for Sensitive Biomedical Analyses. Biosensors and Bioelectronics, 2012, 38, 145-150.
X. Wang, J. Ding, W. Song, K. Xie, W. Qin, Primary-Ion-Conditioned Polymeric Membrane Electrodes for Sensitive Detection of Polyions. Sensors and Actuators B: Chemical, 2012, 161, 1119-1123.