Education

Ph.D., Nanjing University, China
Postdoctoral Research, University of Vermont

Select publications

Mangrum, J. B., Zgani, I., Tsotsoros, S. D., Qu Y., Farrell, N. P., “Zinc Finger Peptide Cleavage By a Dinuclear Platinum Compound”, Chem. Commun., 2013, DOI: 10.1039/C3CC44219E

de Paula, Q. A., Tsotsoros, S. D., Bayse, C., Qu Y., Farrell, N. P., “Reactivity of the Platinum-nucleobases in a PtN₄ Chemophore toward Biomolecules”, Special Volume on Metals in Medicine in Inorganic Chimica Acta. 393. 222-229(2012).

Qu, Y., Moniodis, J. J., Harris, A. L., Yang, X., Hegmans, A., Povirk, L. F., Berners-Price, S. J., Farrell, N. P., “Non-Covalent Polynuclear Platinum Compounds as Polyamine Analogs”, Royal Society of Chemistry, Woster, P.M. Ed. 2012  ISBN: 978-1-84973-309-0  DOI:10.1039/9781849733090-00191

Zhou, Q., Qu, Y., Mangrum, J. B., Wang, X., “DNA Alkylation with N-Methylquinolinium Quinone Methide to N2-dG Adducts Resulting in Extensive Stops in Primer Extension with DNA Polymerases and Subsequent Suppression of GFP Expression in A549 Cells”, Chem. Res. Toxicol. 24: 402–411 (2011).

Qu, Y., Tran, M.-C., Farrell, N., “Structural consequences of a 3′ -> 3′ DNA interstrand cross-link by a trinuclear platinum complex: unique formation of two such cross-links in a 10-mer duplex”, JBIC, Journal of Biological Inorganic Chemistry  (2009),  14(6),  969-977.

Strukl, J. V., de Paula, Q. A., Yang, X., Qu Y., Farrell, N. P., “Comparison of cis and trans-Platinum Mononucleobase Compounds with DNA and Protein Models”, Australian Journal of Chemistry.61: 694-699(2008).

Montero, E. I., Benedetti, B. T., Mangrum, J. B., Oehlsen, M. J., Qu Y., Farrell, N. P., “Pre-association of polynuclear platinum anticancer agents on a protein, human serum albumin. Implications for drug design”, Dalton Trans. 4938–4942(2007).

Williams, J. W., Qu, Y., Bulluss, G. H., Alvorado, E., Farrell, N. P., “Dinuclear Platinum Complexes with Biological Relevance Based on the 1,2-Diamino-cyclohexane Carrier Ligand”, Inorg. Chem. 46: 5820-5822(2007).

Liu, Q., Qu, Y., Van Antwerpen, R., Farell, N., “Mechanism of the Membrane Interaction of Polynuclear Platinum Anticancer Agents. Implications for Cellular Uptake”, Biochemistry 45, 4248 – 4256 (2006).

Oehlsen, M. E., Hegmans, A., Qu, Y., Farrell, N., “Effects of geometric isomerism in dinuclear antitumor platinum complexes on their interactions with N-acetyl-L-methionine”, J. Biol. Inorg. Chem.10:433-442 (2005).