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Fred M. Hawkridge

Postdoctoral with T. Kuwana at Case Western Reserve University and Ohio                                                                                             State University, 3/71 – 8/72.

Ph.D. with H. H. Bauer, University of Kentucky, 6/71.

B. S., University of Georgia, 6/66.  Chemistry

Augusta Junior College, 9/62 – 5/64.

Experience:    

Assistant Professor, Department of Chemistry, University of Southern Mississippi, 9/72 – 8/7

Visiting Scientist, C. F. Kettering Lab 6/75 – 8/75 with Bacon Ke.

Assistant Professor (8/76-8/78), Associate Professor (8/78-8/81) , Professor (8/81-present) Department of                          Chemistry, VCU.

Professor (8/85-present), Department of Biochemistry, VCU.

Visiting Professor, Department of Chemistry, U. of Delaware, 9/81 – 5/82.

Chair, Department of Chemistry, VCU 7/98 – 7/05

Executive Associate Dean for Research and Graduate Affairs, College of

Humanities and Sciences, VCU 7/05 – 8/08.

Interim Dean, College of Humanities and Sciences, 8/08 – present.

National Science Foundation, 8/89 – 7/90, 8/95 – 8/99 Program Officer in the Analytical and Surface Chemistry Program, Division of Chemistry.

Honors:

Japan Society for the Promotion of Science Fellowship, 1987, with Professor Isao Taniguchi, Kumamoto University,                  Japan

Distinguished Scholar Award, College of Humanities and Sciences, VCU, 1988.

Phi Kappa Phi, elected by VCU Chapter 1991.

Creativity Extension, National Science Foundation, 1989-91.

Invited by Norman Hackerman to be a Divisional Editor of Organic & Biological Chemistry for The Journal of The                  Electrochemical Society on March 3, 1989.  Declined, pending year at NSF.

Ph.D. Honoris Causa, St. Petersburg State University, St. Petersburg, Russia, 1993.

A. Benedetti-Pichler Award from the American Microchemical Society, November 2002, for Outstanding                                   Contributions to the Field of Microchemistry.

ACS Division of Analytical Chemistry Award for Distinguished Service in the Advancement of

Analytical Chemistry, September 2003, Sponsored by Waters Corporation.

Distinguished Alumni Award, Department of Chemistry, University of Georgia, October 1, 2010

Research Areas:  Analytical chemistry, electroanalyt­ical chemistry, bioelectrochemistry.  Studies of

heterogen­eous electron transfer thermodynamics, kinetics and mechanisms by biological molecules.

Societies:   American Chemical Society, 1969 – present.

Division of Analytical Chemistry, ACS, 1969 – present.  Treasurer of Division, 1987 to 1990,

Chair Awards, 1999 – 2002, Member of Service Award Jury, 2003-2004.

The Electrochemical Society, 1980 – present, Secretary- Treasurer, 1989-91, Vice Chairman, 1992, Chairman, 1993 for Division of Organic and Biological Electrochemistry. Member of Society Publications Committee and Liaison to AAAS.

American Association for the Advancement of Science, 1976 – present.

Society for Electroanalytical Chemistry, 1984 – present.  Charter member, Membership Committee 1985 – present, Executive Board 1988 – 1992, Chairman of Activities Committee, 1988, Chairman of Reilley Award Selection Committee, 1989 – 1992.

Air Pollution Control Association, 1985 – 1991.

Virginia Academy of Science, 1976 – present.  Advisory Board, 1986 – 1988.

Fellow of the International Union of Pure and Applied Chemistry, 2001- present

Recent Grants:

Department of the Army, Defense Threat Agency, Medical Chemical and Biological Defense Science and Technology Program, “Development of a Cytochrome c Oxidase Based Sensor for Monitoring Respiration and Metabolism,” $303,000, 5/1/05-4/30/07.

ACS Petroleum Research Fund Grants for Scientific Education Type SE, April 1, 2004 – September 30, 2004, $3,600, to support a symposium “Analytical Chemistry in Europe and           Asia at the National ACS Meeting, Anaheim, CA, March 31, 2004.

National Science Foundation, Electron Transfer Reactions Between Cytochrome c, Cytochrome c Oxidase and Dioxygen.  6/15/00 – 5/15/04, $492,700.

Previous support: NSF 19 years, NIH 4 years, Technicon Instruments 2 years, Philip Morris 6

months, duPont 9 months, Research Corporation 1 year.  Total extramural support at VCU

since 1977: $ 3.3 M.

Publications and Patents:

1.      H. H. Bauer, D. Britz, F. M. Hawkridge and A. K. Shallal, “Nega­tive AC Polarographic Waves: Phase Selective Polarograms,” Rev. Polarog. (Kyoto), 18, 141(1971).

2.      F. M. Hawkridge and H. H. Bauer, “Effects of Direct Current Polaro­graphic Maxima on   Alternating Current Waves,” Anal. Chem., 43, 768(1971).

3.      F. M. Hawkridge and H. H. Bauer, “Kinetics and Mechanistic Study of the Reduction of Copper (II) in Lithium Nitrate Using Alternating Current Polarography,” Anal. Chem., 44, 364(1972).

4.      F. M. Hawkridge, T. W. Holt and H. H. Bauer, “Polarographic Maxima of the First Kind: Characterization in the Absence of Resistance-Controlled Currents,” Anal. Chim. Acta, 58, 203(1972).

5.      D. Meyerstein, F. M. Hawkridge and T. Kuwana, “On the Spectroelectro­chemical Characterization of the Electrocatalytic Oxidation of Cu(II) Ethylene Diamine,” J. Electroanal. Chem., 40, 377(1972).

6.      F. M. Hawkridge and T. Kuwana, “Indirect Coulometric Titration of Biological Electron   Transport Components,” Anal. Chem., 45, 1021(1973).

7.      J. C. McPherson, Jr., R. G. Ellison, H. N. Davis, F. M. Hawkridge, L. T. Ellison, “The Metabolic Acidosis Resulting from Intravenous Tetracycline Administration,” Proc. Soc. Exptl. Med., 145, 450 (1974).

8.      B. Ke, F. M. Hawkridge and S. Sahu, “Redox Titration of Fluorescence Yield of Photosystem     II,” Proc. Natl. Acad. Sci. USA, 73, 2211(1976).

9.      B. Ke, E. Dolan, K. Sugahara, F. M. Hawkridge, S. Demeter and E. R. Shaw, “Electrochemical    and Kinetic Evidence for a Transient Electron Acceptor in the Photochemical Charge Separation in Photosystem I,” Plant and Cell Physiol., 187(1977).

10.    F. M. Hawkridge and B. Ke, “An Electrochemical Thin-Layer Cell for Spectroscopic Studies of Photosynthetic Electron-Transport Components,”  Anal. Biochem., 78, 76(1977).

11.    H. L. Landrum, R. T. Salmon and F. M. Hawkridge, “A Surface Modified Gold Minigrid Electrode Which Heterogeneously Reduces Spinach Ferredoxin,” J. Am. Chem. Soc., 99, 3154(1977).

12.    F. M. Hawkridge, J. E. Pemberton and H. N. Blount, “Small Volume, High Performance Cell for Nonaqueous Spectroelectrochemistry,” Anal. Chem., 49, 1646(1977).

13.    J. F. Stargardt, H. L. Landrum and F. M. Hawkridge, “The Reversible Heterogeneous Reduction and Oxidation of Sperm Whale Myoglobin Using a Surface Modified Gold Minigrid Electrode,” Anal. Chem., 50, 930(1978).

14.    L. H. Rickard, H. L. Landrum and F. M. Hawkridge, “A Mediated Electrochemical Redox Study of Soluble Spinach Ferredoxin Using Optically Coupled Methods,” Bioelectrochem. Bioenerget., 5, 676(1978).

15.    A. L. Wade, F. M. Hawkridge and H. P. Williams, “Direct Determination of  Pentachlorophenol by Differential Pulse Polarography,” Anal. Chim. Acta, 105, 91(1979).

16.    D. E. Albertson, H. N. Blount and F. M. Hawkridge, “The Spectroelectrochemical Determination of Heterogeneous Electron Transfer Rate Con­stants,” Anal. Chem., 51, 556(1979).

17.    U. S. Patent #4,144,143, F. M. Hawkridge and H. L. Landrum, VCU, “Electro­lytic Production of a Stable Methyl Viologen Film.”

18.    R. Singleton, Jr., L. L. Campbell and F. M. Hawkridge, “Cytochrome c3 from the Sulfate Reducing Anaerobe, Desulfovibrio africanus ‘Benghazi’: Purification and Properties,” J. Bacteriol., 140, 893(1979).

19.    E. F. Bowden, F. M. Hawkridge and H. N. Blount, “Heterogeneous Electron Transfer Kinetics of Sperm Whale Myoglobin,” Bioelectrochem. Bioenerget., 7, 447(1980).

20.    R. T. Salmon and F. M. Hawkridge, “The Electrochemical Properties of Three Dipyridinium Salts as Mediators,” J. Electroanal. Chem., 112, 253(1980).

21.    C. D. Crawley and F. M. Hawkridge, “Spectroelectrochemical Determina­tion of Heterogeneous Electron Transfer Kinetics of Soluble Spinach Ferredoxin,”    Biochem. Biophys. Res. Commun., 99, 516(1981).

22.    E. E. Bancroft, H. N. Blount and F. M. Hawkridge, “Single Potential Step Chronoabsorptometric Determination of Heterogeneous Electron Transfer Kinetic Parameters of Quasi-Reversible Processes,” Anal. Chem., 53, 1962(1981).

23.    E. E. Bancroft, H. N. Blount and F. M. Hawkridge, “Derivative Cyclic Voltabsorptometry of Cytochrome c,” Biochem. Biophys. Res. Commun., 101, 1331(1981).

24.    E. F. Bowden and F. M. Hawkridge, “Thin-Layer Spectroelectrochemical Kinetic Study of Viologen Cation Radicals Reacting at Hydrogen Evolving Gold and Nickel Electrodes,” J. Electroanal. Chem., 125, 367(1981).

25.    E. E. Bancroft, H. N. Blount and F. M. Hawkridge, “Spectroelectrochem­ical Determination of  Heterogeneous Electron Transfer Kinetic Parameters,” Adv. Chem. Ser., 201, 23(1982).

26.    E. F. Bowden, F. M. Hawkridge and H. N. Blount, “The Heterogeneous Electron Transfer Properties of Cytochrome c,” Adv. Chem. Ser., 201, 159(1982).

27.    E. F. Bowden, D. J. Cohen and F. M. Hawkridge, “Anaerobic Thin-Layer Electrochemical Cell for Planar Optically Transparent Electrodes,” Anal. Chem., 54, 1005(1982).

28.    E. F. Bowden, F. M. Hawkridge, J. F. Chlebowski, E. E. Bancroft, C. Thorpe and H. N. Blount, “The Cyclic Voltammetry and Derivative Cyclic Voltabsorptometry of Purified Horse Heart Cytochrome c,” J. Am. Chem. Soc., 104, 7641(1982).

29.    J. F. Stargardt and F. M. Hawkridge, “Computer Decomposition of the UV-Visible Absorption Spectrum of Methyl Viologen Cation Radical and Methyl Viologen Radical Dimer Containing Solutions,” Anal. Chim. Acta, 146, 1(1983).

30.    J. F. Castner and F. M. Hawkridge, “Heterogeneous Electron Transfer Kinetic Parameters of Metalloproteins as Studied by Channel-Flow Hydrody­namic Voltammetry,” J. Electroanal. Chem., 143, 217(1983).

31.    C. D. Crawley and F. M. Hawkridge, “Rotating Disk Electrode Volt­ammetric Determination of the Heterogeneous Electron Transfer Kinetics of Soluble Spinach Ferredoxin,” J. Electroanal. Chem., 159, 313(1983).

32.    E. F. Bowden, F. M. Hawkridge and H. N. Blount, “Interfacial Electrochemistry of Cytochrome c at Tin Oxide, Gold and Platinum Electrodes,” J. Electroanal. Chem.,161, 355(1984).

33.    D. J. Cohen, F. M. Hawkridge, H. N. Blount and C. R. Hartzell, “The Heterogeneous Electron Transfer Properties of Cytochrome c and the Coupled Cytochrome c/Cytochrome c Oxidase/O2 System,” in “Charge and Field Effects in Biological Systems,” M. J. Allen and P. N. R. Usherwood, eds., Abacus, Tonbridge, United Kingdom, 1984, pp. 19-31.

34.    W. R. Heineman, F. M. Hawkridge and H. N. Blount, “Spectroelectrochem­istry at Optically Transparent Electrodes,” in Electroanalytical Chemistry, A. J. Bard, ed.,Marcel Dekker, New York, Vol. 13, 1984, 1-113.

35.    F. M. Hawkridge, “Electrochemical Cells,” in Techniques in Electroanalytical Chemistry, P. T. Kissinger and W. R. Heineman, eds., Marcel Dekker, New York, 1984, pp. 327-366.

36.    E. F. Bowden, F. M. Hawkridge and H. N. Blount, “Electrochemical Aspects of Bioenergetics,” in Comprehensive Treatise of Electrochemistry, J. O’M. Bockris, B. Conway and E. Yeager, eds., Plenum Press, New York, Vol. 10, 1985, pp. 297-346.

37.     K. B. Koller and F. M. Hawkridge, J. Am. Chem. Soc., 107, 7412- 7417(1985). Temperature and Electrolyte Effects on the Electron Transfer Reactions of Cytochrome c.

38.   R. C. Long, F. M. Hawkridge and C. R. Hartzell, J. Electroanal. Chem., 198, 89-98(1986).  The   Indirect Coulometric Titration of Cytochrome c Oxidase with Cytochrome c.

39.    E. E. Bancroft, H. N. Blount and F. M. Hawkridge, Anal. Chem., 58, 2944-2948(1986).  Asymmetric Double Potential Step Chronoabsorptometric Determination of Heterogeneous    Electron Transfer Kinetic Parameters.

40.    K. B. Koller, F. M. Hawkridge, G. Faque and J. LeGall, Biochem. Biophys. Res. Commun.,         145, 619-624(1987).  Direct Electron Transfer Reactions of Cytochrome c553 from Desulfovibrio Vulgaris Hildenborough at Indium Oxide Electrodes.

41.    D. E. Reed and F. M. Hawkridge, Anal. Chem., 59, 2334-2339(1987).  The Direct Electron Transfer Reactions of Cytochrome c at Silver Electrodes.

42.    B. C. King and F. M. Hawkridge, J. Electroanal. Chem., 237, 81-92(1987).   An Electrochemical Study of Myoglobin Electron Transfer and Oxygen Binding Reactions.

43.    K. B. Koller and F. M. Hawkridge, J. Electroanal. Chem., 239, 291-306(1988). The Effects of Temperature, pH and Electrolyte on the Electron Transfer Reactions of Cytochrome c at Indium Oxide Elec­trodes.

44.    I. Taniguchi, S. Miyamoto, S. Tomimura and F. M. Hawkridge, J. Electro­anal. Chem., 240, 333-339(1988).  Mediated Electron-Transfer of Lactate Oxidase and Sarcosine Oxidase with Octacyanotungstate(IV) and Octacyano­molybdate(IV).

45.    S. Sun, D. E. Reed and F. M. Hawkridge, in “Redox Chemistry and Interfacial Behavior of  Biological Molecules,” G. Dryhurst and K. Niki (eds.)., Plenum Publishing, New York, 1988, pp. 47-61.  “A Study of the Effects of Ionic Strength and Anion Binding on the Reduction Potential of Cytochrome c Using Microelectrodes.”

46.    B. C. King, D. E. Reed, S. Sun, J. Terner and F. M. Hawkridge, “Proceedings of The Seventh Australian Electrochemistry Conference,” 1988, The University of New South Wales, New South Wales, Australia, pp. 241-244.  “Electrochemical Studies of Heme Protein Electron Transfer Rea­ctions.”

47.    R. C. Long, F. M. Hawkridge, J. F. Chlebowski and C. R. Hartzell, J. Electroanal. Chem., 256, 111-125(1988).  The Temperature Dependence and Thermal Denaturation of the Cytochrome  c/Cytochrome c Oxidase/­Dioxygen System, An Electrochemical Investigation.

48.    S. Sun, D. E. Reed, J. K. Cullison, L. H. Rickard and F. M. Hawkridge, “Electron Transfer Reactions of Cytochrome c at Metal Electrodes,” Mikrochimica Acta, III, 97-104(1988).  Invited paper for 50th Anniversary Issue.

49.    B. C. King and F. M. Hawkridge, “Electrochemical Evidence for Facili­tated Oxygen Transport by Myoglobin,” Talanta, 36, 331-334(1989). Invited for special issue on American Science.

50.    Y. Xiaoling, J. K. Cullison, S. Sun and F. M. Hawkridge, “Interfacial Electron Transfer Reactions of Heme Proteins,” in Charge and Field Effects in Biosystems, M. J. Allen, S. C. Cleary and F. M. Hawkridge (eds.), Plenum, New York, 1990, pp. 81-90.

51.    T. Ikeshoji, I. Taniguchi and F. M. Hawkridge, “Electrochemically Distinguished States of Ferricytochrome c and Their Transition with Changes in Temperature and pH.”  J. Electroanal. Chem., 270, 297-308(1989).

52.    M. J. Natan, D. Kuila, W. W. Baxter, Brian M. Hoffman, B. C. King and F. M. Hawkridge, “Heme Ligands Are Probes of Interprotein Electron Transfer Energetics in Mixed-Metal Hemoglobin Hybrids, J. Am. Chem. Soc., 112, 4081-4082(1990).

53.    Y. Xiaoling, S. Sun, I. Taniguchi and F. M. Hawkridge, “Double-Poten­tial Step Chronoelliptometry (DPS/CE): A Direct Measurement of the Rate of Conforma­tion in Cytochrome c,” J. Am. Chem. Soc., 112, 5380-5381 (19­90).

54.    J. K. Cullison, F. M. Hawkridge, N. N. Nakashima and C. R. Hartzell, in “Charge and Field Effects in Biosystems – 3.” M. J. Allen, S. F. Cleary, A. E. Sowers and D. D. Shillady, eds., Burkhauser, Boston, 1992, pp. 29-40, “The Direct Electron Transfer Reactions of Cytochrome Oxidase Immobilized into a Membrane Modified Electrode.”

55.    I. Taniguchi, K. Watanabe, M. Tominaga and F. M. Hawkridge. J.Electroanal. Chem., 333(1992) 331-338.  “Direct Electron Transfer of Horse Heart Myoglobin at an Indium Oxide Electrode.”

56.    I. Taniguchi, H. Kurihara, K. Yoshida, M. Tominaga and F. M. Hawkridge, Denki Kagaku, 12(1992) 1043-1049.  “Electrochemistry of Cytochrome c Components at Indium Oxide and Promoter Modified Electrodes.”

57.    B. C. King, F. M. Hawkridge and B. M. Hoffman, J. Am. Chem. Soc., 114(1992) 10603-10608.  “Electrochemical Studies of Cyanometmyoglobin and Metmyoglobin: Implications for Long-    Range Electron Transfer in Proteins.”

58.    X. Yuan, F. M. Hawkridge and J. F. Chlebowski, J. Electroanal. Chem., 350(1993) 29-42. “Thermodynamic and Kinetic Studies of Cytochrome c from Different Species.”

60.    J. K. Cullison, F. M. Hawkridge, N. Nakashima, S. Yoshikawa, Langmuir, 10(1994) 877-882. “A Study of Cytochrome c Oxidase in Lipid Bilayer Membranes on Electrode Surfaces.”

61.    K. Nishiyama and F. M. Hawkridge, Biochem. Biophys. Res. Commun., 205(1994) 1724-1728.  “Kinetics of Conformation Change in Cyanometmyoglobin Following Electron Transfer as Monitored by Magnetically Induced Circular Dichroism Spectrometry.

62.    P. L. Torkornoo and F. M. Hawkridge, Denki Kagaku, 5(1995) 390-394.  “The Unfolding Effects of Native Myoglobin in Aqueous Urea Studied by Cyclic Voltammetry and Ultraviolet and Visible Absorption Spectroscopy.” Invited article.

63.    F. M. Hawkridge and I. Taniguchi, Comments on Inorganic Chemistry, 17(1995) 163-187.  “The Direct Electron Transfer Reactions of Cytochrome c at Electrode Surfaces.”  Invited

64.    F. M. Hawkridge, “Electrochemical Cells,” in Techniques in Electroanalytical Chemistry, P. T. Kissinger and W. R. Heineman, eds., Marcel Dekker, New York, 1996, pp. 267-291.

65.    J. D. Burgess and F. M. Hawkridge, Langmuir, 13(1997) 3781-3786.  “Octadecyl Mercaptan Sub-monolayers on Silver Electrodeposited on Gold Quartz Crystal Microbalance Electrodes.”

66.    D. J. Cohen, B. C. King and F. M. Hawkridge, J. Electroanal. Chem., 447(1998) 53-62.           “Spectroelectrochemical and Electrochemical Determination of Ligand Binding and Electron Transfer Properties of Myoglobin, Cyanomyoglobin, and Imidazolemyoglobin.”

67.    J. D. Burgess, M. C. Rhoten and F. M. Hawkridge, Langmuir, 14(1998) 2467-2475. “Cytochrome c Oxidase Immobilized in Stable Supported Lipid Bilayer Membranes.”

68.    J. D. Burgess, M. C. Rhoten and F. M. Hawkridge, J. Am. Chem. Soc., 120(1998) 4488-4491.           “Interconversion between Resting and Pulsed Cytochrome c Oxidase in Electrode-Supported Lipid Bilayer Membranes.”

69.    E. Lloyd, A. G. Mauk, B. C. King and F. M. Hawkridge, Inorg. Chem., 37(1998)2888-2892.  “Effect of Electrostatic Alternations on the Ligand Binding and Electrochemical Properties of Horse Heart Myoglobin.”

70.    J. D. Burgess, V. W. Jones, M. D. Porter, M. C. Rhoten, and F. M. Hawkridge, Langmuir,14(1998) 6628-6631.  “Scanning Force Microscopy Images of Cytochrome c Oxidase Immobilized in an Electrode-Supported Lipid Bilayer Membrane.”

71.    L. Duah-Williams and F. M. Hawkridge, J. Electroanal. Chem., 466(1999) 177.  “The Temperature Dependence of the Kinetics of Cyanide Dissociation from the Cyanide Complex of Myoglobin Studied by Cylclic Voltammetry.”

  1. M. C. Rhoten, J. D. Burgess, and F. M. Hawkridge, Electrochim. Acta, 45(2000) 2855-2860 .  “Temperature and pH Effects on Cytochrome c Oxidase Immobilized in an Electrode Supported Lipid Bilayer Membrane.”
  2. F. M. Hawkridge and I. Taniguchi, “Electrochemistry of Heme Proteins,” in “The Porphyrin Handbook,” K. M. Kadish, K. M. Smith, and R. Guilard (Eds.) Academic Press, New York, Chapter 58, 2000,  pp. 191-202.  Review Chapter.
  3. M. C. Rhoten, J. D. Burgess, and F. M. Hawkridge, J. Electroanal. Chem., 534(2002) 143-150.  “The Reaction of Cytochrome C from Different Species with Cytochrome c Oxidase Immobilized in an Electrode Supported Lipid Bilayer Membrane.
  4. M. C. Rhoten, J M. Wilczek, and F. M. Hawkridge, J. Electroanal. Chem., 535(2002) 97-106. “The Reaction of Cytochrome c with Bovine and Bascillus stearothermophilus Cytochrome c Oxidase Immobilized in Electrode-Supported Lipid Bilayer Membranes”

76.    J. D. Burgess and F. M. Hawkridge, “Direct Electron Transfer Reactions of Proteins and Enzymes at Electrodes,”  in “Bioanalytical Electrochemistry,” A. Brajter-Toth and J. Q. Chambers (Eds.), Marcel Dekker, 2002, pp. 109-142.

77.    L. Su, F. M. Hawkridge, and M. C. Rhoten, Chemistry & Biodiversity,  1(2004) 1281-1288.           “Electroreduction of oxygen by cytochrome c oxidase immobilized in electrode-supported lipid    bilayer membranes.”

78.    L. Su, J. B. Kelly, F. M. Hawkridge, and M. C. Rhoten, J. Electroanal. Chem., 580(2005) 241-248.  “Characterization of Cyanide Binding to Cytochrome c Oxidase Immobilized in Electrode-Supported Lipid Bilayer Membranes.”

79.    A. M. Pisarevsky, I. P. Polozova and F. M. Hawkridge, J. Appl. Chem.(Russian), 78(2005) 101-107.  “Chemical Oxygen Demand.”

80.    K. L. Lewis, L. Su, F. M. Hawkridge, K. R. Ward, and M. C. Rhoten, IEEE Sensors, 6(2006) 420-427.  “Immobilization of Cytochrome c Oxidase into Electrode-Supported Lipid Bilayer Membranes for in vitro Cytochrome c Sensing.”

81.    K. R. Ward, R. W. Barbee, J. Terner, R. R. Ivatury, F. M. Hawkridge, US Patent 7,113,814 B2,   “Tissue Interrogation Spectroscopy,” September 2006.

82.    K. R. Ward, S. Brahim, M.C. Rhoten, F. M. Hawkridge, International Patent Application, PCT/US 2006/060821, “Non-Biofouling, Universal Redox Electrode.”  November 2007

82.    US Patent 12/115,460, J. B. Kelly, F. M. Hawkridge, et al., “Detection of Small Ligands with  Metmyoglobin,” May 2008.

83.    US Patent AG01N2726Fl, K. R. Ward, F. M. Hawkridge, S. Brahim, K. L. Lewis, M. C. Rhoten, “Non-Biofouling, Universal Redox Electrode and Measurements System, May 2009.

Invited Talks:

Approximately one hundred twenty including Gordon Research Conference talks on Electro­chemistry (1981 and 2000) and Radical Ions (1981), Reilley Award Symposium (1993).

Contributed Talks

Approximately one hundred ten.

Recent Talks and Presentations

F. M. Hawkridge, Kansas State University, February 5, 1998, “Direct Electrochemical Studies of Cytochrome c Oxidase in Electrode Supported Bilayers.”

F. M. Hawkridge, University of Kansas, February 6, 1998, “Direct Electrochemical Studies of  Cytochrome c Oxidase in Electrode Supported Bilayers.”

M. C. Rhoten and F. M. Hawkridge, Pittsburgh Conference, New Orleans, LA, March 2, 1998, “Characterization of Cytochrome c Oxidase Immobilized in an Electrode-Supported Lipid Bilayer.”

L. Duah-Williams and F. M. Hawkridge, Pittsburgh Conference, New Orleans, LA, March 2, 1998,  “The Temperature Dependence of the Kinetics of Myoglobin Ligand Dissociation Reaction    Dynamics Studied by Cyclic Voltammetry.”

F. M. Hawkridge, University of Pittsburgh, May 14, 1998. “Direct Electrochemical Studies of  Cytochrome c Oxidase in Electrode Supported Bilayers.”

F. M. Hawkridge and M. C. Rhoten, “Direct electron transfer reactions of cytochrome c  oxidase in electrode-supported lipid bilayer membranes,” invited paper in the ACS DAC Award Symposium for Distinguished Service, National ACS Meeting, Boston, MA,August 23, 1998.

F. M. Hawkridge, “Reactions of cytochrome c oxidase in bilayer membranes on electrodes,” invited  Keynote address at the 49th Annual Meeting of the International Society of Electrochemistry,Kitakyushu, Japan, September 14, 1998.

F. M. Hawkridge, “Electron transfer reactions of metalloproteins at electrodes,” 49th Annual ISE Meeting Post-Symposium, Kumamoto, Japan, September 19, 1998.

F. M. Hawkridge, “Metalloprotein electrochemistry and biosensing; present and future,” at the  International Symposium on Bioelectrochemistry of Metalloproteins and Sensing, Kumamoto, Japan, September 21, 1998.

F. M. Hawkridge, “Cytochrome c Oxidase in lipid bilayer membranes on gold electrodes,” in the Symposium “News Electrochemical Approaches in Biology and Materials Sciences,” Southeast Regional ACS Meeting, Raleigh, NC, November 4-7, 1998.

F. M. Hawkridge, “Cytochrome Oxidase in Electrode Supported Bilayers, “ Gordon Research Conference on Electrochemistry, January 17-22, 1999, invited open session talk.

F. M. Hawkridge, ”Electron transfer reactions of cytochrome oxidase in electrode supported lipid bilayers,” First Novartis Science Symposium on Topics in Bioinorganic Chemistry: Metals in Biochemical Systems, University of North Carolina at Greensboro, Greensboro, NC, April 30 –  May 1, 1999.

F. M. Hawkridge, “Cytochrome oxidase in electrode supported lipid bilayer membranes,” University of Kentucky IGERT Program, Lexington, KY, May 17, 1999

F. M. Hawkridge, “Electron Transfer Reactions and Coupled Chemical Reactions of Cytochrome Oxidase in Electrode Supported Bilayer Membranes, Gordon Research Conference on  electrochemistry, January 16-21, 2000.

F. M. Hawkridge, “Studies of Oxidase Modified Bilayer Membrane Electrodes,” University of  Arizona, March 9, 2001.

M. C. Rhoten, K. L. Lewis, and F. M. Hawkridge, “Structure and Properties of  Cytochrome c  Oxidases in Electrode Supported Bilayer Membranes,” Eastern Analytical Symposium, invited   paper in the Findeis Award Symposium, Atlantic City, New Jersey, October 3, 2001.

F. M. Hawkridge, “Studies of Oxidase Modified Bilayer Membrane Electrodes,” Iowa State University, April 12, 2002.

F. M. Hawkridge, “Use of Electrode Supported Bilayers for Direct Electron Transfer with OxidaseEnzymes,” in the ARO/DARPA Bio-Fuel Cells Workshop, Washington, D. C., July 1, 2002.

F. M. Hawkridge, University of Kansas, on the occasion of the retirement of Professor Theodore Kuwana (postdoctoral mentor), October 25-27, 2002.

F. M. Hawkridge, “Reactions of Oxidases in Electrode Supported Bilayers,” Eastern Analytical Symposium, Somerset, NJ, November 21, 2002, invited paper, received the 2002 A. A. Benedetti-Pichler Award from the American Microchemical Society.

F. M. Hawkridge, “Making a Career in Analytical Chemistry,” National ACS Meeting, New York, NY,   September 9, 2003, received the American Chemical Society Division of Analytical Chemistry Award for Distinguished Service.

F. M. Hawkridge, “Electrode Supported Bilayers Containing Oxidase Enzymes: Fundamental and Applied Studies,” College of William and Mary, October 7, 2003.

L. Su, J. B. Kelly, M. C. Rhoten, F. M. Hawkridge, “Electrode Supported Lipid Bilayers Containing Electron Transfer Active Oxidase Enzymes,” poster presentation at the International Symposium on Clusters and Nano-Assemblies: Physical and Biological Systems, Richmond,VA, November 10-13, 2003.

F. M. Hawkridge, J. B Kelly, L. Su, M. C. Rhoten, “Characterization of Monomeric and Dimeric Cytochrome c Oxidase Modified Bilayer Electrodes and Their Applications,” invited talk in the Eastern Analytical Symposium Award for Achievements in the Fields of Analytical Chemistry honoring William R. Heineman, November 19, 2003.

F. M. Hawkridge, “Reactions of Oxidases in Electrode Supported Bilayer Membranes,” invited talk at the 7th UNCW Symposium on Chemistry and Biochemistry, University of North Carolina at Wilmington, January 30-31, 2004.

J. B. Kelly, S. I. Baskin, F. M. Hawkridge, and G. E. Platoff, poster “2-Amino-2-Thiozoline-Carboxylic Acid (ATCA) Appears to Inhibit Cytochrome c Oxidase (CCO),”  Society of Toxicology Meeting, New Orleans, LA, March 6-10, 2005.

J. B. Kelly, L. Su, F. M. Hawkridge, and M. C. Rhoten, poster “Characterization of Cyanide Binding to Cytochrome c Oxidase Immobilized in Electrode-Supported Lipid Bilayer Membranes,” National Meeting of the American Chemical Society, San Diego, CA, March 13-17, 2005

F. M. Hawkridge, “Applications of Oxidase Modified Electrodes,” invited talk at Virginia Section of the ACS Meeting, Longwood University, Farmville, VA, March 24, 2005.

F. M. Hawkridge, “Oxidase Modified Electrodes,” University of Richmond, September 9, 2005.

F. M. Hawkridge, “Sensor Applications of Oxidase Modified Electrodes,” 1st Ernest B. Yeager Frontiers in Electrochemical Science and Electrochemical Technology Symposium, Case Western Reserve University, October 12-14, 2005.

F. M. Hawkridge, “Applications of Oxidase Modified Electrodes,” Symposium Honoring ACS Adamson Award Winner: Steven Bernasek, Princeton University, at the 231st National ACS Meeting, Atlanta, Georgia, March 26-30, 2006.

F. M. Hawkridge, “Electrochemical Detection of Cyanide,” Center for Disease Control Level I    Meeting, Division of Consolidated Laboratory Services, Richmond, VA, April 18-20, 2006.

F. M. Hawkridge, L. Su, M. C. Rhoten, “An Oxidase Modified Electrode for Cyanide Sensing,” in the Chem/Bio Threat Detection Symposium, Southeast Regional ACS Meeting, Augusta, GA, November 1, 2006.

F. M. Hawkridge, Opening Introductory Comments,  Conference on the 175th Anniversary of  Mendelev’s birthday and the 80th Year of the Department of Chemistry at St. Petersburg State University, St. Petersburg, Russia, April 2009.  This honor arose as the first recipient of an Honorary Ph.D. from St. Petersburg State University since the Russian Revolution.

Teaching Experience

At the University of Southern Mississippi (1972-76)

Quantitative Analysis                           (8 semesters)

Electronics                                            (2 semesters)

Instrumental Analysis                           (3 semesters)

Separations (graduate level)                 (1 semester)   new course

General Chemistry                                (3 semesters)

Electrochemistry (grad.)                       (1 semester)   new course

At Virginia Commonwealth University

Quantitative Analysis                           (17 semesters)

Instrumental Analysis                           (10 semesters)

Instrumental Analysis for Forensics     (2 semesters)  new course

General Chemistry                                (11 semesters)

Electrochemistry (grad.)                       (7 semesters)  new course

Advanced Analytical (grad.)                (8 semesters)  new course

Honors Course                                      (3 semesters)  new course

Analytical Spectroscopy (grad.)           (1 semester)  new course

At the University of Delaware

Quantitative Analysis                           (1 semester)

With R. K. Kobos wrote a funded NSF grant to help equip the instrumental analysis laboratory,   1981-82.

Research Advisor to:

Alphonse M. Reed, M. S. 1975, USM, The Use of Diphenylcarbizone as an Analytical Reagent in the Determination of Mercury(II) vis Multiple Internal Reflection Spectroscopy.  Dow Chemical, LA

Lyman H. Rickard, M. S. 1975, USM, An Electrochemical Investigation of the Redox Chemistry of Spinach Ferredoxin.  Professor, Dept. Chemistry, Millersville University.

H. Lynn Landrum, M. S. 1978, USM, An Investigation of a Surface Modified Gold Minigrid Electrode that Heterogeneously Reduces Spinach Fer­redoxin.  Safety Officer, U Southern Miss

Albert L. Wade, M. S. 1978, VCU, Direct Determination of Pentachlorophenol by Differential Pulse Polarography.   Retired.

Richard T. Salmon, M. S. 1979, VCU, Electrochemical Properties of Several Dipyridinium Salts as Electrochemical Mediators.  US Air Force.

Joyce F. Stargardt, M. S. 1981, VCU, Computer Decomposition of the UV-Visible Absorption Spectrum of Methyl Viologen Cation Radical and Methyl Viologen Cation Radical Dimer Containing Solutions.  Scientist, Philip Morris, retired.

James F. Castner, Ph.D. 1981, Heterogeneous Electron Transfer Kinetic Parameters of Hemeproteins as Studied by Channel-Flow Hydrodynamic Voltam­metry.   Scientist, DuPont – Merck.

Charles E. Thomas, M. S. 1982, VCU, Electrochemical Oxidation of Chloro­phyll. Philip Morris Scientist, Retired.

Charlene D. Crawley, M. S. 1982, VCU, Electrochemical Determination of the Heterogeneous Electron Transfer Kinetics of Soluble Spinach Ferredoxin.  (Assistant Professor, Dept. Chemistry, VCU)

Edmond F. Bowden, Ph.D. 1982, VCU, Interfacial Electrochemistry of Cyto­chrome c and myoglobin. (Professor, Dept. Chemistry, North Carolina State University)

Kent B. Koller, Ph.D. 1986, VCU, Electrochemical Investigation of the Effects of Temperature, pH and Electrolyte on the Electron Transfer Reac­tions of Cytochrome c.  Senior Scientist, Philip Morris USA.

Bertha C. King, Ph.D. 1988, VCU, A Study of the Heterogeneous Electron Transfer and Dioxygen Binding Reactions of Myoglobin – Postdoctoral for 12 years, retired, deceased October 2010.

David E. Reed, Ph.D. 1988, VCU, Electrochemical and Surface Enhanced Resonance Raman Study of Heme Proteins at Bare Metal Electrodes.  Scientist, Eli Lilly.

Yuan Xiaoling, Ph.D. 1990, VCU, Conformation Studies of Cytochrome c Proteins in Heterogeneous Electron Transfer Reactions, Medtronics, MN.

John K. Cullison, Ph.D. 1992, VCU, A Study of Cytochrome c Oxidase and Ubiquinone in Bilayer Membranes on Electrode Surfaces.

James D. Burgess, Ph.D. 1998, VCU, “Cytochrome Oxidase Immobilized in Electrode-Supported Lipid Bilayer Membranes” (Associate Professor, Tenured, Dept. Chemistry, Case Western Reserve University).

Lucy Duah-Williams (Ph.D. 1999), VCU, “A Study of Myoglobin Ligand Dissociation Kinetics: An Indirect Model for the In Vivo Dissociation of Dioxygen from Oxymyoglobin.” (Teacher, Governor’s School, Chemistry)

Melissa C. Rhoten (Ph.D. 2000), VCU, “Cytochrome c Oxidase Immobilized in an Electrode-Supported Lipid Bilayer Membrane and Its Reaction with Cytochrome c.”  (Assistant Professor, Longwood College)

Kelvin L. Lewis, (M.S. 2002), VCU, “Direct Potentiometric Technique for Determining the Ratio of Oxidized/Reduced Cytochrome c.”  (Clinical Analyst, Petersburg Hospital)

Service

Reviewer for (average about 50 reviews per year in past, about 25 per year while Dept. Chair, about 10 while Associate Dean, declined on appointment as Interim Dean):

NSF (SBIR panels for six years, RFO panel, mail reviews)

NIH (three years as an ad hoc study section member, Study Section Member in Metallobiochemistry, 1987-91)

DOE, Research Corporation, PRF ACS, NRC, Jeffress Memorial Trust, North Carolina Biotechnology Center

JACS, Anal. Chem., Anal. Chim. Acta, Can. J. Chem., J. Electroanal. Chem., J. Chem. Ed., Electrochem. Soc.

Panel Reviewer for the Air Force Summer Faculty Fellowship Program and the National Defense Science and Engineering Graduate Fellowship Program, Alexandria, VA, February 18-20, 2005, Washington, DC, January 12-13, 2006.

NSF EPSCoR Panel Review for State-wide Infrastructure, December 2009

Coorganizer of many symposia at national meetings of the American Chemical Society and the Electrochemical Society

Coorganized with William R. Heineman a Symposium “Analytical Chemistry in Europe and Asia” at the 227th National American Chemical Society Meeting in Anaheim, CA, March 31, 2004.  Two sessions with eight invited speakers from Europe and Asia.

Local Committees:

Service in many departmental, college and university committees including University Graduate Council (1988-91), University Research Advisory Council (1988-89), ad hoc Honors Program Review Committee, 1990-91, Dean’s Search Committee for Humanities & Sciences, 1991-92, University SACS Self Study Subcommittee on Graduate Programs, 1992-93; Environmental Studies Advisory Committee, 1993-94; University Committee to Study Course and Program Duplication, 1993-94, President of Faculty Council of College of Humanities and Sciences, 1994-95; University Faculty Senate 1995-98; University Council 1997-99, Search Committee Dean of School of Education 2001-   ; CoChair of Task Force on Writing for College of Humanities and Sciences; Member of CB3 Advisory Committee School of Engineering 1999-  ; Member of ad hoc Life Sciences Committee for College, 1999-00; Member of ad hoc Forensic Sciences Committee for College, 1999-01, President’s Advisory Council, 1999- 2003, Proteomics Working Group, 2002-present; Search Committee Dean of Education, 2001-2002; Ad Hoc Restructuring Committee for the College of Humanities and Sciences, 2002-2003; Search Committee for Director of Honors Program, 2002-2003; Search Committee for Departmental Director, Mass Spectrometry Resource Center, 2001-2002; Ad Hoc College Committee for establishing an undergraduate program in Forensic Science, 2001-2004, Chemistry Faculty Search Committee, Chair, 2003-04;  Search Committee for VCU Director of Biological Mass Spectrometry, 2004-2006; Search Committee for Forensic Science Faculty Position, 2004-2005; Search Committee for College of Humanities and Sciences Director of Finance, 2005-2006; Chair of College of Humanities and Sciences Ad Hoc Committee to revise College Bylaws, 2005-2006; Search Committee for Dean of the School of Engineering, 2005-2006; Search Committee for VCU Vice President for Finance, 2005-2006; VCU Research Integrity Officer, Monroe Park Campus, 2006 – present; Analytical Division of ACS Strategic Planning Committee, 2006-2007; Chair, Search Committee for School of Engineering Senior Associate Dean for Research, 2006-present; Member, Search Committee for College of Humanities and Sciences Director of Administration; 2007-2008; Chair, Search Committee for College of Humanities and Sciences Assistant Dean for Student Affairs, 2007-2008;  Co-Chair, University Task Force to Incorporate Community Engagement into University P&T Document, 2007-present, University HEETF Research Equipment Committee, 2006-present.  Member, Search Committee for Director of Mass Spectrometry Facility, 2006-2008.  Member, Search Committee for Director of the Institute for Structural Biology and Drug Discovery, 2008 – present, Member, University Information Technology Assessment Committee, June 2010 – present.

 

State Committees:

Acid Rain Technical Advisory Committee, State of Virginia (1982-1992, 1985-1992, Chairman, voluntary service, managed the Acid Deposition Monitoring Program, provided Quality     Assurance Samples prepared by me in my research laboratories, gathered data, established             reliability of eight independent monitoring stations around the State)

Advisory Committee of the Virginia Academy of Science (1986-90)

Other:

U.S. Editor of Mikrochimica Acta, 1987-1992.

Treasurer of the Analytical Division of the American Chemical Society, 1987-91, jury foreman for several DAC Awards, member of several juries.

Board of Directors, Society for Electroanalytical Chemistry, 1988-92, jury foreman for selection of the C. N. Reilley Awardee, 1989-93, and the SEAC Young Investigator Awardee (1992)

Secretary-Treasurer for the Organic and Biological Division of the Electrochemical Society, 1989-91, Vice Chairman, 1992-3, Chairman 1994-95.

Titular Member of Committee on Electrochemistry, Physical Chemistry Commission, IUPAC, 1994-99, elected Fellow 2002.

Editorial Board, Journal of Electroanalytical Chemistry, 1995-2005.

Editorial Board, Chemistry and Biodiversity, 2004-present.

Jury member for selection of the Benedetti-Pichler Award of the American Microchemical Society, 2003-present.

Advisory Board for the NSF funded Analytical Digital Sciences Library Project at the University of          Kansas/University of California Riverside, 2005-present..

State Council for Higher Education CoReviewer for the proposed Doctorate of Philosophy in   Chemistry at Old Dominion University, prepared and wrote the evaluation report with Professor    Rudolf Jaffe, Director of the Southeast Environmental Research Center at Florida International University, February-March 2006.

Member, Strategic Planning Committee Meeting, Division of Analytical Chemistry, American   Chemical Society, National ACS Meeting, San Francisco, CA, September 8-9, 2006.

External Reviewer for the Departments of Chemistry at East Carolina University, UNC Wilmington,  Old Dominion University, and most recently Hampden-Sydney College, October 2007.

Richmond Kiwanis Club, 2005, Chair Camp Little Hawk Committee (supported summer camp for inner city children in the Richmond City Boys and Girls Club, 2011-12, Board of Directors, 2013 – present.

Consultant

Philip Morris –Richmond, VA, DuPont Experimental Station – Wilmington, DE, Dow Chemical – Midland, MI.